MEN 10207 (acetate)

MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10) -induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10) -induced enhancement of bronchoconstriction in anesthetized guinea pigs[1].

Product Specifications

UNSPSC

12352209

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

N=C(NCCC[C@H](NC([C@H](NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](CC3=CNC4=CC=CC=C34)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)C(C)C)=O)=O)CC6=CNC7=CC=CC=C67)=O)C(N)=O)N.CC(O)=O.[x]

Molecular Formula

C57H68N14O10.xC2H4O2

Molecular Weight

1109.24

References & Citations

[1]Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257 (3) :1172-8.