MOL-6131
MOL-6131 is a highly selective, reversible tryptase inhibitor, with a Ki of 45 nM. MOL-6131 significantly reduces the following features of allergic airway inflammation: eosinophil infiltration in lung tissue, goblet cell hyperplasia and mucus occlusion of airways[1].
Product Specifications
CAS Number
583868-50-2
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(CC1=CC=C(C=C1)N)NCCCC(N2CCC(C3C=CC(N4C(N(CC5=CC=CC6=C5C=CC=C6)C(N43)=O)=O)C(NCC7=CC=C(CN)C=C7)=O)CC2)=O
Molecular Formula
C43H48N8O5
Molecular Weight
756.89
References & Citations
[1]Ni WW, et al. Tryptase inhibitors: a patent review. Expert Opin Ther Pat. 2017 Aug;27 (8) :919-928.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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