(R) -STU104-d6

(R) -STU104-d6 is a deuterium labeled (R) -STU104 (HY-150612) . (R) -STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R) -STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R) -STU104 can be used for researching ulcerative colitis[1].

Product Specifications

CAS Number

[3063042-81-6]

UNSPSC

12352005

Target

Isotope-Labeled Compounds; p38 MAPK

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Cancer

Purity

99.90

Smiles

O=C1C2=CC(OC([2H])([2H])[2H])=CC(OC([2H])([2H])[2H])=C2[C@@H](C3=CC=C(OC)C=C3)C1

Molecular Formula

C18H12D6O4

Molecular Weight

304.37

References & Citations

[1]Tang ML, et al. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R) -STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65 (9) :6690-6709.