Otenaproxesul (Standard)
Otenaproxesul (Standard) is the analytical standard of Otenaproxesul. This product is intended for research and analytical applications. Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2) . Otenaproxesul possesses antiinflammatory and antinociceptive activities[1][4].
Product Specifications
CAS Number
1226895-20-0
UNSPSC
12352100
Target
Apoptosis; COX; Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
COC1=CC=C(C=C(C(C)C(OC2=CC=C(C(N)=S)C=C2)=O)C=C3)C3=C1
Molecular Formula
C21H19NO3S
Molecular Weight
365.45
References & Citations
[1]John L Wallace, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346) . Br J Pharmacol. 2010 Mar;159 (6) :1236-46.|[2]Paola De Cicco, et al. ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo. Pharmacol Res. 2016 Dec;114:67-73.|[3]Bruno Schneider Herrera, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4.|[4]panelEduardoEkundi-Valentim, et al. P4 Antiinflammatory and antinociceptive effects of ATB-346, a gastric sparing hydrogen sulfide-releasing naproxen, in rats with carrageenan-induced knee joint synovitis. Nitric Oxide. Volume 27, Supplement 2, 15 September 2012, Page S13.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400806-100 1x 100 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TP312185 20 µg
Breast cancer suppressor candidate 1 (VWA5A) (NM_014622) Human Recombinant Protein
Sign In for Pricing
View Details 
