(R) -SM875
(R) -SM875 is a degrader targeting the intermediate folding form of prion protein (PrP) . (R) -SM875 significantly reduces the PrP level, with an IC50 of 3 μM. (R) -SM875 can be used for the study of prion diseases[1].
Product Specifications
CAS Number
[2715974-36-8]
UNSPSC
12352005
Target
Prion Protein
Related Pathways
Neuronal Signaling
Field of Research
Infection
Smiles
O=C1NC2=C(C=NN2C3=CC=C(C=C3)Br)[C@@H](C4=CC(OC)=C(C=C4)O)C1
Molecular Formula
C19H16BrN3O3
Molecular Weight
414.25
References & Citations
[1]Innocenti N, et al. Enantiomers of the prion protein degrader SM875: Production and configurational assignment, in silico analysis and in vitro evaluation. Bioorg Chem. 2025 Jul 1;161:108489.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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