(R) -SM875

(R) -SM875 is a degrader targeting the intermediate folding form of prion protein (PrP) . (R) -SM875 significantly reduces the PrP level, with an IC50 of 3 μM. (R) -SM875 can be used for the study of prion diseases[1].

Product Specifications

CAS Number

[2715974-36-8]

UNSPSC

12352005

Target

Prion Protein

Related Pathways

Neuronal Signaling

Field of Research

Infection

Smiles

O=C1NC2=C(C=NN2C3=CC=C(C=C3)Br)[C@@H](C4=CC(OC)=C(C=C4)O)C1

Molecular Formula

C19H16BrN3O3

Molecular Weight

414.25

References & Citations

[1]Innocenti N, et al. Enantiomers of the prion protein degrader SM875: Production and configurational assignment, in silico analysis and in vitro evaluation. Bioorg Chem. 2025 Jul 1;161:108489.