SM875
SM875 is a cellular prion protein (PrP) degrader (IC50: 7.87 μM) . SM875 targets PrP folding intermediates and promotes its degradation through the autophagy-lysosomal pathway. SM875 only acts on nascent, immature PrP molecules and has no effect on mature PrP before synthesis. SM875 can inhibit prion replication and has potential in the study of neurodegenerative diseases (i.e., prion diseases) [1].
Product Specifications
CAS Number
919023-94-2
UNSPSC
12352005
Target
Prion Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
98.89
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(C(C1)C3=CC=C(C(OC)=C3)O)C=NN2C4=CC=C(C=C4)Br
Molecular Formula
C19H16BrN3O3
Molecular Weight
414.25
References & Citations
[1]Spagnolli G, et al. Pharmacological inactivation of the prion protein by targeting a folding intermediate. Commun Biol. 2021 Jan 12;4 (1) :62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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