Ironomycin
Ironomycin is a derivative of Salinomycin. Ironomycin exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin blocks the cell cycle and induces apoptosis and ferroptosis. Ironomycin induces double-strand DNA breaks and activates the unfolded protein response (UPR), particularly the IRE1α signaling pathway accumulation. The combination of Ironomycin with Ibrutinib (HY-10997) shows a synergistic effect. Ironomycin can be used for the study of MCL.
Product Specifications
CAS Number
1884647-72-6
UNSPSC
12352005
Target
Apoptosis; Caspase; CDK; DNA/RNA Synthesis; Drug Derivative; Ferroptosis; IRE1
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
Molecular Formula
C45H73NO10
Molecular Weight
788.06
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9; CDK4
Available Sizes
Frequently Asked Questions
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