Sildenafil-d5

Sildenafil-d5 (UK-92480-d5) is deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

Product Specifications

CAS Number

[951385-70-9]

Product Name Alternative

UK-92480-d5

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease; Cancer

Smiles

O=C1N=C(C2=C(OC([2H])([2H])C([2H])([2H])[2H])C=CC(S(=O)(N3CCN(CC3)C)=O)=C2)NC4=C1N(C)N=C4CCC

Molecular Formula

C22H25D5N6O4S

Molecular Weight

479.61

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[3]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.|[4]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[5]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.