Sildenafil (Standard)

Sildenafil (Standard) is the analytical standard of Sildenafil. This product is intended for research and analytical applications. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

Product Specifications

CAS Number

[139755-83-2]

UNSPSC

12352100

Target

Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE) ; Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease; Cancer

Smiles

O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1

Molecular Formula

C22H30N6O4S

Molecular Weight

474.58

References & Citations

[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.|[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.