Cligosiban (Standard)
Cligosiban (Standard) is the analytical standard of Cligosiban. This product is intended for research and analytical applications. Cligosiban (PF-3274167) is an orally active, highly selective, and centrally permeable oxytocin receptor antagonist with good pharmacokinetics in rats and can inhibit physiological ejaculation in rodents[1][2].
Product Specifications
CAS Number
900510-03-4
UNSPSC
12352100
Target
Oxytocin Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Endocrinology
Smiles
FC1=CC(Cl)=C(OC2CN(C3=NN=C(COC)N3C4=CC=C(OC)N=C4)C2)C=C1
Molecular Formula
C19H19ClFN5O3
Molecular Weight
419.84
References & Citations
[1]Wayman C, et al. Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents. J Sex Med. 2018 Dec;15 (12) :1698-1706. |[2]Yue X, et al. Pharmacokinetics, bioavailability and metabolism of cligosiban, an antagonist of oxytocin receptor, in rat by liquid chromatography hyphenated with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2019 Feb 5;164:725-733. |[3]Badshah M, et al. The Effects of Age on Prostatic Responses to Oxytocin and the Effects of Antagonists. Biomedicines. 2023 Nov 1;11 (11) :2956. |[4]Badshah M, et al. Age-Dependent Effects of Oxytocin and Oxytocin Receptor Antagonists on Bladder Contractions: Implications for the Treatment of Overactive Bladder Syndrome. Biomedicines. 2024 Mar 18;12 (3) :674.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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