20:4 Lyso PI

20:4 Lyso PI is a selective G protein-coupled receptor GPR55 agonist. 20:4 Lyso PI triggers cell rounding in GPR55-expressing HEK293 cells, with an EC50 value of 10 nM. 20:4 Lyso PI promotes RhoA activation and subsequent ROCK-dependent cytoskeletal rearrangement. 20:4 Lyso PI activates the ERK signaling pathway and elevates intracellular free calcium. 20:4 Lyso PI can be used for the study of immune diseases[1].

Product Specifications

CAS Number

[1246430-04-5]

UNSPSC

12352211

Target

Calcium Channel; ERK; GPR55

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

O[C@H]1[C@@H](OP(O)(OC[C@@H](COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)O)=O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O

Molecular Formula

C29H49O12P

Molecular Weight

620.67

References & Citations

[1]Nakajima K, et al. Lysophosphatidylinositol Induced Morphological Changes and Stress Fiber Formation through the GPR55-RhoA-ROCK Pathway. Int J Mol Sci. 2022 Sep 18;23 (18) :10932.