Inosine 5'-triphosphate (lithium salt)

Inosine-5'-triphosphate (ITP) lithium salt is a nucleotide analogue that acts on multiple G proteins. Inosine-5'-triphosphate lithium salt can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Inosine-5'-triphosphate lithium salt interacts with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. Inosine-5'-triphosphate lithium salt is used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes[1][2][3][4].

Product Specifications

CAS Number

[3056945-75-3]

Product Name Alternative

ITP (lithium salt) ; Inosine triphosphate (lithium salt)

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C1N=CNC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)[C@@H](O)[C@H]3O

Molecular Formula

C10H11Li4N4O14P3

Molecular Weight

531.90

References & Citations

[1]Hanson RL, et al. Energy-transducing adenosine triphosphatase from Escherichia coli: purification, properties, and inhibition by antibody. J Bacteriol. 1973 May;114 (2) :772-81.|[2]Pieper U, et al. The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol. 1999 Sep 24;292 (3) :547-56.|[3]Klinker JF, et al. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochem Pharmacol. 1997 Sep 1;54 (5) :551-62.|[4]Burnstock G, et al. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol. 1972 Mar;44 (3) :451-61.