(E/Z) -OT-R antagonist 1

(E/Z) -OT-R antagonist 1 is a mixture of E/Z forms of OT-R antagonist 1 (HY-15015) . OT-R antagonist 1 is a novel, potent, selective non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activation (IC50 = 8 nM) [1][2][3][4].

Product Specifications

CAS Number

[364076-99-3]

UNSPSC

12352005

Target

Oxytocin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Smiles

O=C([C@H](C/1)N(C(C2=CC=C(C3=C(C)C=CC=C3)C=C2)=O)CC1=N/OC)NC[C@@H](O)C4=CC=CC=C4

Molecular Formula

C28H29N3O4

Molecular Weight

471.55

References & Citations

[1]Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors. WO/2001072705/A1. |[2]Cirillo R, et al. Pharmacology of (2S,4Z) -N-[ (2S) -2-hydroxy-2-phenylethyl]-4- (methoxyimino) -1-[ (2'-methyl[1,1'-biphenyl]-4-yl) carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J Pharmacol Exp Ther. 2003 Jul;306 (1) :253-61.|[3]William Nadler, et al. Method for preparing pyrrolidine oximes. WO/2005082848/A2.|[4]Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors.WO/2001074769/A1.