GSK951
GSK951 is a potent and selective Kallikrein-5 (KLK5) inhibitor amenable to epidermal delivery. GSK951 shows an IC50 of 250 pM for KLK5 and greater than 100-fold selectivity over KLK7 and KLK14. GSK951 can reduce transepidermal water loss, and decrease proinflammatory cytokine expression. GSK951 can be used for the researches of inflammation and immunology, such as Netherton syndrome[1].
Product Specifications
CAS Number
2393881-77-9
UNSPSC
12352005
Target
Kallikrein
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
OB1C2=CC(C(F)(F)F)=CC=C2C[C@@](C3=CC(OCC4=CN=CC=C4)=C(C=C3)C(N)=N)([H])O1
Molecular Formula
C22H19BF3N3O3
Molecular Weight
441.21
References & Citations
[1]Liddle J, et al. A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome. J Invest Dermatol. 2021 Sep;141 (9) :2272-2279.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KLK5
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