CZS-241 (hydrochloride)
CZS-241 hydrochloride is an orally active and selective inhibitor of Polo-like Kinase 4 (PLK4) (IC50=2.6 nM) . CZS-241 hydrochloride inhibits TRKA with an IC50 value of 2.74 μM. CZS-241 hydrochloride induces apoptosis and arrests cell cycle at S/G2 phase. CZS-241 hydrochloride shows highly potent antiproliferative activity against leukemia cell lines, and exhibits safety against normal cell lines[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Polo-like Kinase (PLK) ; Trk Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC1=CC=C(C=C1NC(C2=C(C=CC(CNC3=NC4=C(C(NC5=NNC(C)=C5)=N3)C=NN4C(C)C)=C2)Cl)=O)F.Cl
Molecular Formula
C26H25Cl2F2N9O
Molecular Weight
588.44
References & Citations
[1]Sun Y, et al. Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia. J Med Chem. 2023 Feb 23;66 (4) :2396-2421.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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