N6022 (Standard)

N6022 (Standard) is the analytical standard of N6022. This product is intended for research and analytical applications. N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 8 nM.

Product Specifications

CAS Number

[1208315-24-5]

UNSPSC

12352100

Target

GSNOR; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

OC(CCC1=CC=C(N1C2=CC=C(C(N)=O)C=C2C)C(C=C3)=CC=C3N4C=CN=C4)=O

Molecular Formula

C24H22N4O3

Molecular Weight

414.46

References & Citations

[1]Sun X, et al. Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3671-5.|[2]Colagiovanni DB, et al. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regul Toxicol Pharmacol. 2012 Feb;62 (1) :115-24.|[3]Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51 (10) :2157-68.|[4]Thomas M. Raffay, et al. Methods of treating respiratory disorders. Patent. US 20170209419 A1.