Tazolol
Tazolol is a specific β-adrenergic antagonist (IC50: 700 nM for (-) isoproterenol-elicited accumulation of cyclic AMP in rat cortical slices) . Tazolol produces a significant and sustained increase in cardiac output and stroke volume. Tazolol can be used in the research of heart failure[1][2].
Product Specifications
CAS Number
39832-48-9
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
OC(CNC(C)C)COC1=NC=CS1
Molecular Formula
C9H16N2O2S
Molecular Weight
216.30
References & Citations
[1]Skolnick, et al. Blockade of central beta-adrenergic receptors by tazolol (1-isopropylamino-3- (2-thiazoloxy) -2-propanol) . Life Sci. 1977 Dec 1;21 (11) :1655-63. |[2]Buckley HT, et al. Circulatory effects of tazolol in experimental myocardial infarction. Am J Cardiol. 1975 May;35 (5) :619-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor
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