Ac4-5SGlcNAc
Ac4-5SGlcNAc is a pro-inhibitor of carbohydrate-based glycosyltransferases (OGTs) . Ac4-5SGlcNAc inhibits o-GlcN acylation and interferes with the effects of o-GlcN on neural induction of human embryonic stem cells (hESCs), and reduces the invasive phenotype of breast cancer cells. Ac4-5SGlcNAc also targets other carbohydrate-processing enzymes[1].
Product Specifications
CAS Number
67561-97-1
UNSPSC
12352005
Target
Biochemical Assay Reagents
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(O[C@H]1[C@@H]([C@H](S[C@@H]([C@@H]1NC(C)=O)OC(C)=O)COC(C)=O)OC(C)=O)=O
Molecular Formula
C16H23NO9S
Molecular Weight
405.42
References & Citations
[1]Barkovskaya A, et al. Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Sci Rep. 2020 Oct 12;10 (1) :16992.|[2]Andres LM, et al. Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation. ACS Chem Biol. 2017 Aug 18;12 (8) :2030-2039.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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