Dalcetrapib (Standard)

Dalcetrapib (Standard) is the analytical standard of Dalcetrapib. This product is intended for research and analytical applications. Dalcetrapib (JTT-705) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50s of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively[1][2].

Product Specifications

CAS Number

[211513-37-0]

UNSPSC

12352100

Target

CETP; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease; Cancer

Smiles

CC(C)C(SC1=C(NC(C2(CC(CC)CC)CCCCC2)=O)C=CC=C1)=O

Molecular Formula

C23H35NO2S

Molecular Weight

389.59

References & Citations

[1]Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51 (12), 3443-3454.|[2]Shinkai H, et al. J Med Chem. bis (2- (Acylamino) phenyl) disulfides, 2- (acylamino) benzenethiols, and S- (2- (acylamino) phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. 2000, 43 (19), 3566-3572.|[3]Huang Z, et al. Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells. Am J Physiol Endocrinol Metab. 2003, 284 (6), E1210-E1219.