3-Hydroxy darifenacin

3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033) . 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells[1].

Product Specifications

CAS Number

[206048-82-0]

UNSPSC

12352005

Hazard Statement

H302+H312+H332-H315-H319

Target

Drug Metabolite; mAChR

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CC3)CCC4=CC=C(OCC5O)C5=C4)=O

Molecular Formula

C28H30N2O3

Molecular Weight

442.55

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Mansfield KJ, et al. Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. J Pharmacol Exp Ther. 2009 Mar;328 (3) :893-9.