3,7,2',4'-Tetramethoxy-5-hydroxyflavone

BCRP/ABCG2-IN-1 is the inhibitor of breast cancer resistance protein (BCRP/ABCG2), with IC50 of 5.98 μM, that can be used in multidrug resistance of breast cancer[1].

Product Specifications

CAS Number

[19056-75-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

BCRP

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O=C1C(OC)=C(C2=C(OC)C=C(OC)C=C2)OC3=C1C(O)=CC(OC)=C3

Molecular Formula

C19H18O7

Molecular Weight

358.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kapil Juvale, et al. Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2. Eur J Med Chem. 2013 Sep:67:115-26.