JMX0254

JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections[1].

Product Specifications

CAS Number

[2375960-04-4]

UNSPSC

12352005

Target

Dengue Virus; Virus Protease

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C1[C@@]2(C3=C(NC(C2)=O)N(N=N3)[C@H](C4=CC=C(C=C4)Cl)C)C5=CC(Cl)=CC=C5N1CCC(C)C

Molecular Formula

C25H25Cl2N5O2

Molecular Weight

498.40

References & Citations

[1]Xu J, et al. Design, synthesis, and biological evaluation of substituted 4, 6-dihydrospiro [[1, 2, 3] triazolo [4, 5-b] pyridine-7, 3′-indoline]-2′, 5 (3 H) -dione analogues as potent NS4B inhibitors for the treatment of dengue virus infection[J]. Journal of medicinal chemistry, 2019, 62 (17) : 7941-7960.