JMX0254
JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections[1].
Product Specifications
CAS Number
2375960-04-4
UNSPSC
12352005
Target
Dengue Virus; Virus Protease
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1[C@@]2(C3=C(NC(C2)=O)N(N=N3)[C@H](C4=CC=C(C=C4)Cl)C)C5=CC(Cl)=CC=C5N1CCC(C)C
Molecular Formula
C25H25Cl2N5O2
Molecular Weight
498.40
References & Citations
[1]Xu J, et al. Design, synthesis, and biological evaluation of substituted 4, 6-dihydrospiro [[1, 2, 3] triazolo [4, 5-b] pyridine-7, 3′-indoline]-2′, 5 (3 H) -dione analogues as potent NS4B inhibitors for the treatment of dengue virus infection[J]. Journal of medicinal chemistry, 2019, 62 (17) : 7941-7960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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