Pafuramidine (Standard)
Pafuramidine (Standard) is the analytical standard of Pafuramidine. This product is intended for research and analytical applications. Pafuramidine (DB289) is an orally active proagent of Furamidine. Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria[1][2][3].
Product Specifications
CAS Number
186953-56-0
Product Name Alternative
DB289 (Standard)
UNSPSC
12352005
Target
Antibiotic; Parasite; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(NOC)=N)C=C3)O2)C=C1)NOC
Molecular Formula
C20H20N4O3
Molecular Weight
364.40
References & Citations
[1]Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis (4-amidinophenyl) - furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53 (3) :953-7.|[2]Pohlig G, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS Negl Trop Dis. 2016 Feb 16;10 (2) :e0004363.|[3]Chen D, et al. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. Expert Rev Anti Infect Ther. 2007 Dec;5 (6) :921-8.|[4]Purfield AE, et al. Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro. Antimicrob Agents Chemother. 2008 Jun;52 (6) :2253-5.|[5]Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis (4-amidinophenyl) - furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53 (3) :953-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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