Lificiguat (Standard)

Lificiguat (Standard) is the analytical standard of Lificiguat. This product is intended for research and analytical applications. Lificiguat binds to the β subunit of soluble guanylyl cyclase (sGC) with Kd of 0.6-1.1 μM in the presence of CO.

Product Specifications

CAS Number

[170632-47-0]

UNSPSC

12352100

Target

Guanylate Cyclase; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cancer; Cardiovascular Disease

Smiles

OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1

Molecular Formula

C19H16N2O2

Molecular Weight

304.34

References & Citations

[1]Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53 (1) :101-14.|[2]Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.|[3]Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171 (17) :4010-25.|[4]Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.