Lificiguat (Standard)
Lificiguat (Standard) is the analytical standard of Lificiguat. This product is intended for research and analytical applications. Lificiguat binds to the β subunit of soluble guanylyl cyclase (sGC) with Kd of 0.6-1.1 μM in the presence of CO.
Product Specifications
CAS Number
170632-47-0
UNSPSC
12352100
Target
Guanylate Cyclase; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Cancer; Cardiovascular Disease
Smiles
OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
Molecular Formula
C19H16N2O2
Molecular Weight
304.34
References & Citations
[1]Purohit R, et al. YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry. 2014 Jan 14;53 (1) :101-14.|[2]Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.|[3]Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171 (17) :4010-25.|[4]Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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