FSH receptor antagonist 1
FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G (s) -protein-coupled human follicle-stimulating hormone (FSH) receptor. FSH receptor antagonist 1 exhibits an IC50 of 28 nM on a cell line expressing the human FSH receptor. FSH receptor antagonist 1 significantly inhibits follicle growth and ovulation in an ex vivo mouse model[1].
Product Specifications
CAS Number
487064-35-7
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C4C(C(C)(CC(C)(C)N4C(C)=O)C5=CC=CC=C5)=C3
Molecular Formula
C33H32N2O2
Molecular Weight
488.62
References & Citations
[1]Straten NCR, et, al. Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor. J Med Chem. 2005 Mar 24;48 (6) :1697-700.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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