PtdIns- (3) -P1 (1,2-dipalmitoyl) (ammonium)

PtdIns- (3) -P1 (1,2-dipalmitoyl) (Compound 7) ammonium is a derivative of phosphatidylinositol 3-phosphate (PtdIns (3) P) . phosphatidylinositol 3-phosphate can bind to the FYVE domain of human EEA1 and act as a second messenger in cellular signaling and membrane trafficking. phosphatidylinositol 3-phosphate can stimulate ROS formation by regulating the neutrophil oxidase complex[1][2][3].

Product Specifications

Product Name Alternative

DPPI-3-P (ammonium) ; PIP[3'] (16:0/16:0) (ammonium) ; PI (3) P (16:0/16:0) (ammonium)

UNSPSC

12352211

Target

Drug Derivative; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Others

Smiles

CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(O[C@@H]1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)O)OP([O-])(O)=O)O)([O-])=O)=O.[NH4+].[NH4+]

Molecular Formula

C41H86N2O16P2

Molecular Weight

925.07

References & Citations

[1]Gokhale NA, et al. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005 Dec 30;280 (52) :42831-40. |[2]Ellson CD, et al. PtdIns (3) P regulates the neutrophil oxidase complex by binding to the PX domain of p40 (phox) . Nat Cell Biol. 2001 Jul;3 (7) :679-82. |[3]Kutateladze TG, et al. Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell. 1999 Jun;3 (6) :805-11.