PBF-999
PBF-999 is a phosphodiesterase10A (PDE-10A) and adenosine A2A receptor (A2AR) dual antagonist. PBF-999 binds to and inhibits the activity of PDE-10A, thereby preventing the degradation of cGMP. PBF-999 can be used for the study of solid tumour advanced cancer[1].
Product Specifications
CAS Number
[1620909-95-6]
UNSPSC
12352005
Target
Adenosine Receptor; Phosphodiesterase (PDE)
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
BrC1=C(NCC#C)N=C(N2N=CN=C2)N=C1N
Molecular Formula
C9H8BrN7
Molecular Weight
294.11
References & Citations
[1]Yu F, et al. Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2020 Nov 12;63 (21) :12196-12212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Adenosine A2A receptor (A2AR) ; PDE10
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