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PBF-999

PBF-999 is a phosphodiesterase10A (PDE-10A) and adenosine A2A receptor (A2AR) dual antagonist. PBF-999 binds to and inhibits the activity of PDE-10A, thereby preventing the degradation of cGMP. PBF-999 can be used for the study of solid tumour advanced cancer[1].

Product Specifications

CAS Number

1620909-95-6

UNSPSC

12352005

Target

Adenosine Receptor; Phosphodiesterase (PDE)

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

BrC1=C(NCC#C)N=C(N2N=CN=C2)N=C1N

Molecular Formula

C9H8BrN7

Molecular Weight

294.11

References & Citations

[1]Yu F, et al. Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2020 Nov 12;63 (21) :12196-12212.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Adenosine A2A receptor (A2AR) ; PDE10

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