Avibactam (free acid) (Standard)

Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid) . This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

Product Specifications

CAS Number

[1192500-31-4]

Product Name Alternative

NXL-104 (free acid) (Standard)

UNSPSC

12352005

Target

Antibiotic; Bacterial; Beta-lactamase; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O)=O

Molecular Formula

C7H11N3O6S

Molecular Weight

265.24

References & Citations

[1]Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109 (29) :11663-8.|[2]Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104) . J Antimicrob Chemother. 2012 Jun;67 (6) :1354-8.|[3]Berkhout J, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2299-304.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.