Avibactam (sodium hydrate) (Standard)
Avibactam (sodium hydrate) (Standard) is the analytical standard of Avibactam (sodium hydrate) . This product is intended for research and analytical applications. Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
Product Specifications
CAS Number
2938989-90-1
Product Name Alternative
NXL-104 (hydrate) (Standard)
UNSPSC
12352005
Target
Antibiotic; Bacterial; Beta-lactamase; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O.O
Molecular Formula
C7H12N3NaO7S
Molecular Weight
305.24
References & Citations
[1]Ehmann DE, et al.
 Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.
 Proc Natl Acad Sci U S A. 2012 Jul 17;109 (29) :11663-8.|[2]Livermore DM, et al.
 Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104) .
 J Antimicrob Chemother. 2012 Jun;67 (6) :1354-8.|[3]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2299-304.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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