PTX-BD10-2

PTX-BD10-2 (BD10-2) is an orally active TrkB/C modulator. PTX-BD10-2 ameliorates BFCN degeneration. PTX-BD10-2 restores cholinergic neurite integrity, alleviates cholinergic neurite atrophy. PTX-BD10-2 can be used in the research of Alzheimer's disease[1].

Product Specifications

CAS Number

[1627834-10-9]

Product Name Alternative

BD10-2

UNSPSC

12352005

Target

Trk Receptor

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

COCCN(CCOC)C1=CC=C(C(C)C2=CC=C(N(CCOC)CCOC)C=C2)C=C1

Molecular Formula

C26H40N2O4

Molecular Weight

444.61

References & Citations

[1]Gonzalez S, et al. Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage. Neurobiol Dis. 2022 Jan;162:105563.