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Butyzamide (GMP)

Butyzamide (GMP) is Butyzamide produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay[1].

Product Specifications

CAS Number

1110767-45-7

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

JAK; p38 MAPK; STAT

Related Pathways

Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cardiovascular Disease

Smiles

CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC

Molecular Formula

C29H32Cl2N2O5S

Molecular Weight

591.55

Precautions

H315, H319, H335

References & Citations

[1]Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93 (10) :1495-504.

Shipping Conditions

Blue Ice

Storage Conditions

Keep sealed and protect from light, store at 2-8°C

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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