Revamilast
Revamilast (GRC 4039) is an orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 3 nM. Revamilast inhibits the production of TNF-α. It can be used for research on rheumatoid arthritis, plaque psoriasis, asthma, and other inflammatory diseases[1].
Product Specifications
CAS Number
[893555-90-3]
Product Name Alternative
GRC 4039
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(C2=C3C=CN=C2)C(O3)=C(OC(F)F)C=C1)NC4=C(Cl)C=[N+]([O-])C=C4Cl
Molecular Formula
C18H9Cl2F2N3O4
Molecular Weight
440.18
References & Citations
[1]Li H, Zuo J, Tang W. Phosphodiesterase-4 inhibitors for the treatment of inflammatory diseases. Frontiers in pharmacology. 2018 Oct 17;9:1048.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE4
Curated Selection
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