ZJH-16
ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM) . ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers[1].
Product Specifications
CAS Number
2877017-58-6
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2
Molecular Formula
C18H14N6O
Molecular Weight
330.34
References & Citations
[1]Dong G, et al. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED-H3K27me3 Inhibitors for the Treatment of Lymphoma. J Med Chem. 2023 Jan 12;66 (1) :1063-1081.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-P835285-2.5MG 2.5 mg
Propane-1,3-diylbis((3-acetamidopropyl)carbamic Acid) di-tert-Butyl Ester
Sign In for Pricing
View Details 
![FITC Anti-Human CD86 Antibody[IT2.2]](https://cdn.genprice.uk/products/763/68dd14a5061270361e7d18a0/imageurl/e-ab-f1269c.webp)