Picoberin
Picoberin is a low picomolar inhibitor of Hedgehog-induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes[1].
Product Specifications
CAS Number
[3034663-23-2]
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Smiles
O=C1N2[C@@H](CC3=CC(Cl)=C(C=C31)Br)C4=C(CC2)C=CC=C4
Molecular Formula
C17H13BrClNO
Molecular Weight
362.65
References & Citations
[1]Flegel, J., et al., (2022) . The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. Journal of medicinal chemistry, 65 (24), 16268-16289.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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