Picoberin

Picoberin is a low picomolar inhibitor of Hedgehog-induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes[1].

Product Specifications

CAS Number

[3034663-23-2]

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Smiles

O=C1N2[C@@H](CC3=CC(Cl)=C(C=C31)Br)C4=C(CC2)C=CC=C4

Molecular Formula

C17H13BrClNO

Molecular Weight

362.65

References & Citations

[1]Flegel, J., et al., (2022) . The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. Journal of medicinal chemistry, 65 (24), 16268-16289.