HTS13286
HTS13286 is a novel AQP9 inhibitor. HTS13286 prevents the LPS-induced increase of NO. HTS13286 reduces glucose output. HTS13286 can be used in the research of endotoxin shock[1].
Product Specifications
CAS Number
[727359-12-8]
UNSPSC
12352005
Target
Aquaporin; NO Synthase
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Metabolic Disease
Smiles
O=C(CSC1=NN=C(N1C)C2=CC=NC=C2)NC3=NN=C(C4=CC=CS4)S3
Molecular Formula
C16H13N7OS3
Molecular Weight
415.52
References & Citations
[1]Jelen S, et al. Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. J Biol Chem. 2011 Dec 30;286 (52) :44319-25. |[2]Tesse A, et al. Aquaporin-9 (AQP9) exerts a role in the early phase of the systemic inflammation of a murine model of endotoxic shock[J]. Physiology, 2024, 39 (S1) : 1193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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