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Tecarfarin-13C, d3

Tecarfarin-13C, d3 (ATI-5923-13C, d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin has the antithrombotic activity [2].

Product Specifications

Product Name Alternative

ATI-5923-13C, d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds; VKOR

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=CC=C(CC2=C(O)C3=C(C=CC=C3)OC2=O)C=C1)OC(C(F)(F)F)(C(F)(F)F)[13C]([2H])([2H])[2H]

Molecular Formula

C20 13CH11D3F6O5

Molecular Weight

464.33

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117 (11) :2009-2011.|[3]Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4- ((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126 (5) :e383-8.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-14854S/

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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