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Tafamidis (Standard)

Tafamidis (Standard) is the analytical standard of Tafamidis. This product is intended for research and analytical applications. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].

Product Specifications

CAS Number

594839-88-0

UNSPSC

12352100

Target

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) ; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Neurological Disease

Smiles

O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O

Molecular Formula

C14H7Cl2NO3

Molecular Weight

308.12

References & Citations

[1]Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109 (24) : p. 9629-34.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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