Tafamidis meglumine (Standard)
Tafamidis meglumine (Standard) is the analytical standard of Tafamidis meglumine. This product is intended for research and analytical applications. Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1].
Product Specifications
CAS Number
951395-08-7
UNSPSC
12352100
Target
Reference Standards; Transthyretin (TTR)
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O.O[C@@H]([C@@H]([C@@H](CO)O)O)[C@@H](O)CNC
Molecular Formula
C21H24Cl2N2O8
Molecular Weight
503.33
References & Citations
[1]Bulawa CE, et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9629-34.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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