Levomequitazine
Levomequitazine (Compound V0114) ((S) -Mequitazine), the levorotatory enantiomer of Mequitazine , is an orally active, inverse H4 receptor agonist (IC50s: 94 nM (hM2), 17 nM (hM3) ). Levomequitazine strongly binds to human histamine H4 receptor. Levomequitazine antagonizes the activating action induced by histamine on H4 receptor. Levomequitazine induces a powerful and statistically significant anti-inflammatory effect. Levomequitazine can be used for research on inflammatory diseases[1].
Product Specifications
CAS Number
88598-74-7
Product Name Alternative
(S) -Mequitazine
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Isomer; Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
N1(C2=CC=CC=C2SC3=CC=CC=C31)C[C@H]4C5CCN(CC5)C4
Molecular Formula
C20H22N2S
Molecular Weight
322.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Thierry Clerc, et al. Mequitazine for treating or preventing pathologies involving histamine h4 receptors. WO2009071625A1. WIPO (PCT) . 2008-12-04.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
Phase 3
Frequently Asked Questions
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