(+) -Arhalofenate
(+) -Arhalofenate ((+) -MBX 102) is the less active enantiomer of Arhalofenate. Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR) -γ, used for the treatment of type 2 diabetes[1][2][3].
Product Specifications
CAS Number
1030594-28-5
Product Name Alternative
(+) -MBX 102; (+) -JNJ 39659100
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.85
Smiles
O=C(OCCNC(C)=O)[C@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C19H17ClF3NO4
Molecular Weight
415.79
References & Citations
[1]Gregoire FM, et al. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23 (7) :975-88.|[2]Chandalia A, et al. MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation. PPAR Res. 2009;2009:706852.|[3]Kenneth L. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia. WO2000074666A2
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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