(+) -Arhalofenate

(+) -Arhalofenate ((+) -MBX 102) is the less active enantiomer of Arhalofenate (HY-14831) . Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR) -γ, used for the treatment of type 2 diabetes[1][2][3].

Product Specifications

CAS Number

[1030594-28-5]

Product Name Alternative

(+) -MBX 102; (+) -JNJ 39659100

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.85

Smiles

O=C(OCCNC(C)=O)[C@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2

Molecular Formula

C19H17ClF3NO4

Molecular Weight

415.79

References & Citations

[1]Gregoire FM, et al. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23 (7) :975-88.|[2]Chandalia A, et al. MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation. PPAR Res. 2009;2009:706852.|[3]Kenneth L. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia. WO2000074666A2