Succinyl CoA

Succinyl CoA is an intermediate of the citric acid cycle. Succinyl CoA can be converted to succinic acid and can also combines with glycine to form δ-amino levulinic acid (ALA) to synthesize porphyrins (heme) . Succinyl CoA can be used in the study of metabolic, neurological and haematological abnormalities (such as porphyrias) caused by nutritional vitamin B12 deficiency (resulting in a deficiency in Succinyl CoA synthesis) [1][2].

Product Specifications

CAS Number

[604-98-8]

Product Name Alternative

Succinyl-coenzyme A; S- (Hydrogen succinyl) coenzyme A

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32

Molecular Formula

C25H40N7O19P3S

Molecular Weight

867.61

References & Citations

[1]Bicakci Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore) . 2015 Mar;94 (9) :e584. |[2]Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3 (1) :365-401.