Sobetirome (Standard)

Sobetirome (Standard) is the analytical standard of Sobetirome. This product is intended for research and analytical applications. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ) -specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM[1].

Product Specifications

CAS Number

[211110-63-3]

UNSPSC

12352100

Target

Reference Standards; Thyroid Hormone Receptor

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Endocrinology

Smiles

O=C(O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1

Molecular Formula

C20H24O4

Molecular Weight

328.40

References & Citations

[1]Gierach I, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.|[2]Johansson L, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102 (29) :10297-302.|[3]Villicev CM, et al. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr;193 (1) :21-9.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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