Sobetirome (GMP)
Sobetirome (GMP) is Sobetirome produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ) -specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM[1].
Product Specifications
CAS Number
211110-63-3
Product Name Alternative
GC-1 (GMP) ; QRX-431 (GMP)
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C(O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1
Molecular Formula
C20H24O4
Molecular Weight
328.40
References & Citations
[1]Gierach I, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.|[2]Johansson L, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102 (29) :10297-302.|[3]Villicev CM, et al. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr;193 (1) :21-9.
Shipping Conditions
Blue Ice
Storage Conditions
Keep sealed and protect from light, store at 2-8°C
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Frequently Asked Questions
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