MEL23

MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription[1].

Product Specifications

CAS Number

[642072-49-9]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1NC(C(C2NCCC3=C2NC4=C3C=CC=C4)C(N1CCCC)=O)=O

Molecular Formula

C19H22N4O3

Molecular Weight

354.40

References & Citations

[1]Divya Venkatesh, et al. MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. Genes Dev. 2020 Apr 1;34 (7-8) :526-543.|[2]Herman AG, et al. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011 Sep;1 (4) :312-25.