NSC 330770
NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC50 of 2 μM) . NSC 330770 elicites GTPase activity and the formation of abnormal polymers[1].
Product Specifications
CAS Number
[82585-91-9]
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(N)=C2N=C(CNC2=C1)C3=CC=CC=C3)OCC
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
References & Citations
[1]Barbier P, et al. Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes. Biochemistry. 1995 Dec 26;34 (51) :16821-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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