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Inolitazone (hydrochloride hydrate)

Inolitazone hydrochloride hydrate (Efatutazone hydrochloride hydrate) is a novel PPARγ high-affinity agonist, with an EC50 value one-fiftieth that of Rosiglitazone , and shows no inhibitory effect on RIE cells that do not express PPARγ. Inolitazone hydrochloride hydrate can be used in the research of cancer[1][2].

Product Specifications

CAS Number

1048002-36-3

Product Name Alternative

Efatutazone (hydrochloride hydrate) ; CS-7017 (hydrochloride hydrate) ; RS5444 (hydrochloride hydrate)

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=C(N)C(C)=CC(OC2=CC(N(C)C(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)=N5)=C5C=C2)=C1.O.Cl.Cl

Molecular Formula

C27H30Cl2N4O5S

Molecular Weight

593.52

References & Citations

[1]Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25 (16) :2304-17.|[2]Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69 (4) :1536-44.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PPARγ

Frequently Asked Questions

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