(S) -Human enteropeptidase-IN-1

(S) -Human enteropeptidase-IN-1 (Compound 6c) is an orally active enteropeptidase inhibitor with low systemic exposure (IC50 (initial) : 26 nM; IC50 (app) : 1.8 nM) . (S) -Human enteropeptidase-IN-1 promotes increased fecal protein output and effectively reduces body weight in a diet-induced obese (DIO) rat model. (S) -Human enteropeptidase-IN-1 inhibits enteropeptidase via a reversible covalent mechanism and prolongs the enzyme inactivation time. (S) -Human enteropeptidase-IN-1 can be used in anti-obesity research[1].

Product Specifications

CAS Number

[1802891-23-1]

UNSPSC

12352211

Target

Enteropeptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C([C@@]1(CC(O)=O)CC(C2=CC=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=NO1)O

Molecular Formula

C20H18N4O7

Molecular Weight

426.38

References & Citations

[1]Ikeda Z, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity. J Med Chem. 2022 Jun 23;65 (12) :8456-8477.